Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease.
نویسندگان
چکیده
Animal and epidemiologic studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of Parkinson disease (PD). The authors studied 1,258 PD cases and 6,638 controls from the General Practice Research Database. The odds ratios (95% CI) for ever vs never use were 0.93 (0.80 to 1.08) for nonaspirin NSAIDs, 1.29 (1.05 to 1.58) for aspirin, and 1.16 (1.00 to 1.35) for acetaminophen. Nonaspirin NSAID use was associated with a higher risk in women and a lower risk in men.
منابع مشابه
Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis.
BACKGROUND/OBJECTIVE Anti-inflammatory drugs may prevent Parkinson disease (PD) by inhibiting a putative underlying neuroinflammatory process. We tested the hypothesis that anti-inflammatory drugs reduce PD incidence and that there are differential effects by type of anti-inflammatory, duration of use, or intensity of use. METHODS MEDLINE and EMBASE were searched for studies that reported ris...
متن کاملInteractions of stroke, nonsteroidal anti-inflammatory drugs, and APOE status in dementia risk.
5 Interactions of stroke, nonsteroidal anti-inflammatory drugs, and APOE status in dementia risk 7 ␣-Synuclein gene duplications in sporadic Parkinson disease Jessie Theuns and Christine Van Broeckhoven ARTICLES 9 Joint effect of stroke and APOE 4 on dementia risk: The Canadian Study of Health and Aging 43 ␣-Synuclein gene duplication is present in sporadic Parkinson disease
متن کاملA Rare Complication with the Concomitant use of Warfarin and Nonsteroidal Anti-Inflammatory Drugs: Hemoperitoneum and Intramural Small Bowel Hematoma
متن کامل
Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease.
OBJECTIVE To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). DESIGN Family-based case-control study. SETTING Academic medical center clinic. PARTICIPANTS A total of 356 case subjects and 317 family controls who self-reported en...
متن کاملAnti-inflammatory drugs in the texts of traditional Iranian Medicine (Tim)
Nonsteroidal anti-inflamatory drugs (NSAIDs) and glucocorticoids, nowaday are the main groups of anti-inflamatory drugs in modern pharmacology. The side effects of these antiinflamatory drugs, specially using in chronic diseases cause many problems for the patients and the physicians, so finding the new anti-inflamatory drugs with less side effect is the aim of many researchers. WHO emphasiz to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neurology
دوره 66 7 شماره
صفحات -
تاریخ انتشار 2006